New research suggests that repeated mRNA vaccination induces limited immune tolerance for the spike protein

Once again, it is time to stop vaccinating.

Dec 27, 2022

These are IgG1, IgG2, IgG3 and IgG4 antibody levels in 29 study participants before vaccination (“before”), ten days after dose 1 (“post 1st”), ten days after dose 2 (“post 2nd”), 210 days after dose 2 (“FU post 2nd”), ten days after dose 3 (“post 3rd”), and 180 days after dose 3 (“FU post 3rd”). Ten of the 29 participants were infected after their third dose; their antibody levels are marked in grey. IgG1 and IgG3 antibodies trigger broader, inflammatory immune responses to clear infection. IgG2 and IgG4 antibodies, meanwhile, do roughly the opposite. The more IgG4 you have, the less aggressively you’ll respond to infection. Repeated mRNA vaccination is associated both with lower levels of the key infection-fighting IgG3 antibody, and with much higher levels of the antigen-tolerating IgG4 antibody, especially in vaccinees who suffered breakthrough infections.

“Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination” is the title of a new Science: Immunology paper by researchers at Erlangen, in Germany.

I write about this with reluctance, partly because it’s already been covered by friends-of-the blog Rintrah Radagast, el gato malo, Igor Chudov and now Alex Berenson; partly because I really think that whatever is happening or will happen with Corona, we desperately need to transition to a world where we stop worrying about virus infections, particularly infections with Corona; and partly because I’m still not convinced of the significance of these findings. But, this is also a plague chronicle, and I won’t ignore anything here.

In short, it looks like repeated mRNA vaccination induces a partial immune tolerance of the spike protein. Adenovirus vector vaccines don’t cause this tolerance. The spike protein on its own doesn’t either. Nor do vaccines against other pathogens cause this kind of tolerance for their respective antigens. Everything suggests it’s a property of the mRNA technology in particular.

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