If they hadn't spliced Omicron spike onto ancestral SARS-2, though, we never would've known that "major determinants of viral pathogenicity reside outside of S," so there's that
What the hell is wrong with these people.
It takes a lot to gast my flabber these days but this one has done it. It is as if the last three years haven't happened for these people and they are just beavering away in their little white rooms creating doom for humanity without a care in the world.
"none of this research will have any meaningful payoff to compensate for the incredible risk, or any real salutary purpose at all [...] scientists need publications to secure grant funding and further their careers and SARS-2 is a hot topic right now. That is the only reason"
I love this particular point because it is absolutely true. People often like to imagine elaborate conspiracy theories run by mysterious villains. But in reality a lot of Stupid Stuff or Scary Stuff happens because some rank-and-file with highly specialized competence in one domain and complete ignorance of 2nd order effects and complex systems takes initiative to promote his/her own agenda. I am sure this is true also at the highest echelons of power, where arrays of mid-managers can effectively filter (and distort) information towards the top
If only someone would do us the favor of incinerating every single biolab on the planet, preferably within a two minute window ala Breaking Bad, so that we can also be done with these mad scientists who won’t stop until they kill us all.
If I were a politician I would run on one and only one issue. End all viral research. Destroy all labs, life imprisonment to everyone up and down the chain of command. President of universities, directors of NIH & NIAID, researchers, big pharma execs... everyone.
100% full stop. World-wide.
One spilled vial, one escaped humanized mouse. One cage with a speck of mouse poop or spittle could kill 6 billion humans! Not to mention one emotionally unstable lab tech who hates humanity.
This research is the height of arrogance.
There are not enough exclamations to make this point.
Re "I do know that the pandemic has left us with a serious problem, namely legions of eager virologists tinkering with SARS-2 in labs all over the world. These guys were a serious problem before the pandemic, but now there are many more of them and they have never had so much funding."
Who is funding these dangerous people?
The US National Institute of Allergy and Infectious Diseases / National Institutes of Health for instance...
It was the NIAID which funded the controversial H5N1 studies which emerged in late 2011, see: What really happened in Malta this September when contagious bird flu was first announced? Scientific American: https://blogs.scientificamerican.com/observations/what-really-happened-in-malta-this-september-when-contagious-bird-flu-was-first-announced/
The NIAID was funding studies into making H5N1 more transmissible, this became known as dual use research, and then gain of function.
It's unbloodybelievable what the US has been doing in laboratories over the years, and goodness knows who else.
I complained about this reckless research at the time, questioning if it contravened the Biological Weapons Convention, see my emails:
- An open letter to the NSABB re the political and ethical implications of lethal virus development, 31 January 2012: http://users.on.net/~peter.hart/Open_Letter_to_Paul_Keim_NSABB_31_Jan_2012.pdf
- A submission to the Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS) re Opposition to Lab-engineering of Potentially Lethal Pathogens, 17 December 2012: http://users.on.net/~peter.hart/Submission_to_CDC_HHS.pdf
Anthony Fauci has been director of NIAID since 1984 - has anyone tried to calculate the damage this man has caused in the world over the years, e.g. by funding gain of function research?
It's incredible this guy is still sitting in that position - 38 years!
Fauci should have been on trial years ago...it's mindboggling to think about the amount of damage he has wreaked upon the world.
Wow, just thinking about his impact re Covid alone is incalculable...
When the car companies did some gain-of-function research to better fit their engines to the emission test bench, everybody was shocked. SHOCKED!
You would ask why do the do it? The answer is always the same - because the can! The consequences simply never come to mind.
I am no technical expert but if this configures as gain of function research isn't it forbidden in the US? I have no issue with R&D so long the ultimate purpose is clear: if it is about creating vaccines pre-emptively than it should be about pathogens that can evolve naturally, otherwise it looks more as bacteriological weaponization or something along those lines.
Gan of function research like this should be banned outright with penalties commensurate with the degree of harm and death which results from actual lab releases, such as COVID-19. Leaks cannot be entirely prevented, so creating variants like this puts every human and probably many non-human animals at great risk - firstly from the novel infection itself and secondly from a world full of harm, death, government overreach, quasi-vaccines, mandates, lockdowns, social isolation, economic destruction etc even if they are not infected..
Anyone who is not transfixed by the allure of vaccines, quasi-vaccines, monoclonal antibodies, drugs and all the research funding and profits which drive work on these - anyone with an actual interest in humanity and our immune systems - will soon find that most people have only 1/10 to 1/2 of the circulating 25-hydroxyvitamin D their immune system needs to mount full-strength innate and adaptive responses to viral, bacterial and fungal pathogens, and to cancer, and to avoid wildly dysregulated inflammatory (indiscriminate cell-killing) responses. See Quraishi et al. 2014 cited in the two links below.
With this knowledge, drugs (including ivermectin), masks, lockdowns etc. etc. are of no immediate interest. All that matters is getting most people to supplement enough vitamin D3 to attain the 50 ng/mL 125 nmol/L 25-hydroxyvitamin D their immune systems need in order to work properly. Fortunately, this is a tiny amount - 1/8th of a milligram a day for 70 kg 154 lb body weight. Other nutrients are important, including boron, magnesium, at least some of the B vitamins, zinc and especially omega 3 fatty acids, but no nutritional deficiency is so acute, ubiquitous and easily corrected as vitamin D. This is a gram every 22 years, and pharma grade vitamin D3 costs about $2.50 a gram ex-factory.
All these doctors and researchers sincerely believe they are doing heroic work poking around with this drug, that spike protein configuration - and that they should be lauded and financially rewarded for these supposedly great efforts at saving humanity. If they really care about people's health, rather than their own careers, they should read the research cited in: https://www.mdpi.com/2072-6643/14/14/2997/htm (Prof. Sunil Wimalawansa's "Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections - Sepsis and COVID-19") and https://vitamindstopscovid.info/00-evi/ .
On the theme of mad scientists I recall that during the theorising and making of the very first atom bomb some of the experts involved seriously thought there was the possibility of their dream of nuclear fission starting a chain reaction which would destroy the earth.
But they still carried on...
It's nice to see that that thought process pervades the frontiers of virology.
Dr Strangelove is coming to a place near us and expect the new improved gain-of-function version......
Not just Boston researchers, university of Mainz, Germany as well. If you go to the actual paper, you’ll spot affiliation number 12: Mainz. Now who just happens to be headquartered in Mainz? Not that miracle of German vaccinology, BioNTech, whose partnership with Pfizer earned the city of Mainz megabucks in local tax revenues.
Perhaps this research conveniently finds the conclusion that "the pathogenicity resides outside the spike protein"..... to take blame away from the spike inducing vaccines??
The thought that so much misery has been caused by curious people thinking "Well.. why not...?"
And we will keep doing this, trial & error is what our species is all about. Often we've been lucky - sometimes, mostly recently, not so much. And the stales are so much higher now than in the past, when a lot of trial & error did not end in the creation of a deadly virus but a slightly better plough design.
Why are we letting this happen?