The study also finds evidence of ADE by the REGEN-COV/Ronapreve monoclonal antibodies
Just wanted to say thanks for all the valuable information you've shared over the past couple years....
E: "This an in-vitro study; it doesn’t look at clinical outcomes; things that seem bad in a cell culture might not mean very much in real life."
Waddaya mean?!?! Didn't they just approve the super-juice based on in-vitro study of antibodies of 8 mice? :-P
Thank you for this. Work product like this is what gave me the determination and strength to get through the last year as an unvaxxed in Austria. And the dividends continue. Having learned of some vax injuries in our circles, and having sailed through omicron easily without the vax, my kids trust me deeply and respect my opinion in a way that will probably carry on for a very long time. My husband also very grateful I’d begged him to wait until more evidence came out about these products. After just a couple months into the vax campaign no further begging was needed. 🙏
Remember public health agencies and the media urging healthy young people to "get vaccinated for the sake of others"? Ha ha ha! And then to think they ostracized the unvaxxed because they thought we were a danger to everyone else.
So, everyone who was concerned about the potential for ADE back when they were telling us "that will never happen" is being vindicated. Although, even without this study it has become evident in data, that the further out from increasing boosters, the more likely death becomes. So I don't really think it matters that this is in vitro. It merely confirms real world observations.
Process question: Does any of this mean Pfizer has to stop pimping their juice? Because if so, that's a no-no! The Golden Goose is still laying eggs! Stated differently, at what point will any of these studies make the assholery of people like POTUS Biden, or Trudeau in Canada, or a host of other assholes around the World, obviously evil and force it to stop? My guts says, "Never" but might be a bit of a pessimist after 2 years of complete lunacy.
Honestly the biggest takeaway for me was this:
>Recent studies have demonstrated several mechanisms leading to ADE, which can be FcR-dependent but ACE2-independent, FcR-independent but ACE2-dependent, S-protein conformational change-dependent, or both FcR- and ACE2-dependent ADE12,23,24,25,30.
ADE works through a variety of very different mechanisms, some of which we know about and perhaps some of which we may not know about. This virus is basically an expert in Aikido: It is skilled in a wide variety of methods to use its opponents moves against him.
Based on this and another recent paper, my conviction has been further reinforced that the different Omicron lineages are now convergently evolving towards whatever form allows them to make optimal use of the artificially homogenized human antibody response.
And so you'll have negative efficacy of these vaccines, not just because the immune response produced is inferior to natural immunity, but also because the virus will continue to recall those antibodies that help enhance its replication cycle.
To me that looks like an existential threat, born from an unprecedented idiotic experiment.
Do you think given it’s complexities, researchers should stop tinkering with the immune system?
Sometimes it's awful to be vindicated.
Thank you for your nuanced commentary, which highlights the deep complexity of virology and epidemiology. Contrast your analysis with this stupidity from Rachel Maddow, who has hundreds of thousands of listeners: "Now we know that the vaccines work well enough that the virus stops with every vaccinated person. A vaccinated person gets exposed to the virus, the virus does not infect them, the virus cannot then use that person to go anywhere else," she added with a shrug. "It cannot use a vaccinated person as a host to go get more people. [Vaccines] will get us to the end of this." - Rachel Maddow, March 2021
8 mice > 6 in-vitro
BOW DOWN TO THE SCIENCE!!
we are so screwed
Just as a point of clarification. The paper is presented as being published in Nature but it is actually in the much lower tier Scientific Reports which although part of the nature publishing group, papers in such journals are not typically spoken of as published in Nature. Still very interesting.
I received Sotrovimab monoclonals last Christmas. Hope I am ok....
The CDC recently reported on long covid for different groups, including by sexual orientation to see how it is impacting the gay and trans communities.
But no breakdown of long covid by vaxxed vs. unvaxxed status, since that is irrelevant information from their view. https://www.cdc.gov/nchs/covid19/pulse/long-covid.htm
Thanks for this balanced explanation, very intriguing.
Dr. JJ Couey called out ADE risk publicy as early as 4-22 2020, when I first heard him explain it. He also explained the improper use of PCR tests with clear potential for false positives being rolled out at the same time. He was calling out the unnaturalness of the virus with specific evidence in concert with many colleagues. Quite a hat trick. And now he is released from his two decades long academic position.
That information turned my attention, along with Dr. Chris Martenson's concerns voiced on Peak Prosperity, to searching even more carefully for credible science information ever since (PubMed and active scientists in many fields) and beyond what media were telling us. To this day, I trust the two of these people for ongoing insights. May have saved many lives including mine.