A small study of breakthrough infections provides further evidence that Omicron likely benefits from immune imprinting, or Original Antigenic Sin, in the vaccinated. The authors, mostly from UC San Francisco and UC Berkeley, conducted neutralisation assays on 144 plasma samples from 81 individuals, 63 of them double-vaccinated, and 18 of them boosted. None of the subjects had been infected prior to vaccination, but 53 suffered breakthrough infections. Thirty-nine of these breakthroughs were probably Delta, and 14 were Omicron.
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